Prior Approval Drug List | BCBSVT
Prior Approval Drug List | BCBSVT
Blue Cross Blue Shield of Vermont requires prior approval for certain prescriptions. Review the list of drugs requiring approval.

Transactivates pregnane X receptor (Expert Opin Drug Metab Toxicol 4:895,2008) ~75% metab, mostly by CYP2C9 (Br J Clin Pharm 50:573,2000; Clin Pharmacol Therap 76:557,2004). Substrate,inducer and inhibitor of CYP3A4; pregnane X receptor inducer www. Metab to 5-fluorouracil, which does not induce CYPs (Drug Metab Disp 32:762,2004; Canad J Physiol Pharmacol 74:150,1996) www. Compare the 8-aminoquinoline primaquine: Inducer of CYPs 1A1, 1A2 and 1B1 www. Does not induce CYP3A4 or transactivate pregnane X receptor (USP DI? Drug Info.

Substrate & inhibitor of CYP3A4 Sinz: Cur Drug Metab 2006; 7:375: no human pregnane X receptor activation www. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Not Porphyrinogenic 2 Patient reports: Safe No transactivation of pregnane X receptor (Curr Drug Metab 6:375,2006) www. E: Basic Clin Pharmacol Toxicol 2007; 100:4: Substrate mainly of CYP2D6, less of 3A4. Substrate of CYP3A, but excreted mostly unchanged, and does not induce CYPs (Mol Pharmacol 65:1302,2004;Clin Pharm Therap 80:565,2006) Experience of P.

Metabolized in liver, but 50% in bile unchanged & 35% metabolized by demethylation Patient reports: safe www. Use PV Tishler MD clinical data & patient reports: Safe Not a substrate for & does not induce CYPs (Fundam Clin Pharmacol 14:301,2000; Clin Therapeutics 30:1385,2008) www. Lemke T and Williams DA. Does not transactivate pregnane X receptor (Curr Drug Metab 7:375,2006) www. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Lemke T and Williams DA. Small amt metab by CYP2D6,?other CYPs (Drug Metab Disp 36:769,2008) web. Does not induce CYPs (Cur Med Therap 15:2193,2008; Med Letter 49:97,2007). Induces CYP3A4 & 2B6, & does transactivate pregnane X receptor (Pharmaceutical Res 23:1089,2006; Eur J Pharm Sci 11:185,2000; Drug Metab Disp 31:439,2003; Curr Drug Metab 7:375,2006) Patient report: Safe www. Did not affect expression of PXR and MDR1 in zebrafish.



Wikipedia:WikiProject Pharmacology/List of drugs - Wikipedia
How It Is Named. For generic names, this is the agency which has designated that name. [eg , , or ] for brand names, this is the company which produces that brand. Peginterferon alfa 2a generic lexapro OLANZapine (Professional Patient Advice) - Drugs.comProfessional guide for OLANZapine. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.

CYP2C9; metab by CYP3A4 probably minimal, but induces CYP3A4 via transactivation of pregnane X receptor (Pharmacokinet 45:1061,2006; Epilepsia 46:378,2005; Arch Toxicol 82:667,2008; Clin Therapeutics 30:1385,2008) 1 patient report: safe www. Induces CYP2B6,3A4 via transactivation of constitutive androstane rerceptor & pregnane X receptor (Pharmacogenet Genomics 19:300, 2009; Arch Toxicol 82:667,2008; J Pharmacol Exp Therap 320:72,2007; Clin. Induces CYP3A4 & transactivates pregnane X receptor but at concns. Possibly Porphyrinogenic metab mainly by & induces CYP3A4, also CYP3A5 (Drug Metab Disp 35:350,2007. Use PV Tishler MD clinical data & patient reports: Safe Metab by liver, presumably by CYPs; inhibits several CYPs also (Drug Metab Dispos 1997;25:390) www.

Cur Durg Metab 2006; 7:375: No activation of pregnane X rerceptor. Induces CYP3A4 via transactivation of pregnane X receptor (Williams DA. Safe in patients Does not induce CYP3A4 or trnasactivate pregnane X receptor (Cancer Chemother Pharmacol 64:35,2009). Extensively metab by CYP3A4,2D6 (Xenobiotica 28:909, 1998; PDR 63:848,2009). Curr Drukg Metab 7:375,2006) PV Tishler MD clinical data, 3 patient reports: Safe https://online.

Baltimore, Williams & Wilkins, 6th ed, 2007; Clin Pharm Therap 85:78,2008) www. Administered in low weekly dose, probably insignificant hepatic exposure. Induces CYP3A4 but does not transactivate pregnane X receptor (Fundam Clin Pharmacol 14:301,2000; Curr Drug Metab 7:375,2006; Clin Therapeutics 30:1385,2008) www. Use with care in doses >2 mL (of 10 mg/mL solution) Clin Pharmacol Ther 1998;64:484. Curr Drug Metab 7:375, 2006; Drug Safety 29:769, 2006) 7 patient reports: safe www. Ed: Metabolized primarily by CYP2B6 (also CNS Drugs 2012; 26:39) & CYP2D6; Moderately transactivates pregnane X receptor but has low probability of inducing CYP3A4 (Curr Drug Metab 9:598,2008; CYP1A2, to lesser extent by CYP3A & other CYPs. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. Unsafe Largely not CYP metab; some metab by multiple CYP2C9 but not CYP3A4. X receptor & low prediction of clinical induction (Basic Clin Pharmacol Toxicol 100:4,2007; Cur Drug Metab 7:375,2006; Curr Drug Metab 11:516,2010) www. Does not transactivate pregnane X receptor (Williams DA.


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